United States securities and exchange commission logo August 29, 2022 Willie Chiang Chairman and Chief Executive Officer Plains GP Holding, L.P. 333 Clay Street Suite 1600 Houston, TX 77002 Re: Plains GP Holdings, L.P. Form 10-K for Fiscal Year Ended December 31, 2021 Filed March 1, 2022 File No. 001-36132 Dear Mr. Chiang: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Energy & Transportation